Post menopausal vaginal atrophy study

Research status

Completed

Overview of Study

A prospective randomised study of two vaginal preparations on vaginal atrophy, sexual function and well being in post menopausal women. Women were assigned in a 2:1 ratio to ESTring and Vagifem and followed for 12 months.

Objectives of study

The major aims of the study were to compare the safety of a continuous low-dose estradiol-releasing vaginal ring (ESTring) to that of a vaginal estradiol tablet (Vagifem) on the endometrium and the relief of subjective symptoms and signs of urogenital estrogen deficiency. Quality of life and acceptability of treatment delivery were also assessed.

Published articles

Endometrial and vaginal effects of low-dose estradiol delivered by vaginal ring or vaginal tablet